The responsible physician typically takes great care to interview their patient, considering a variety of factors before making a diagnosis and prescribing the particular antidepressant they feel will work best to treat depression for that individual. It should be noted that all of these name-brand antidepressants can have serious side effects. Many pet owners, who have chosen to treat their pet’s condition in this manner, claim that Rover, who used to bite or obsessively chase his tail, now behaves nicely, making him a much better pet. How can a veterinarian possibly ‘interview’ a pet? How is a diagnosis of depression made? Is it known that the negative side effects manifest in an animal in the same way a human might experience these red flags?